已有文献报道,表面活性剂、螯合剂、水杨酸盐类、抗炎药及碱性氨基酸盐类等能增强多种化合物的胃肠道通透性。虽然这些吸收促进剂的作用机理尚未明了,但很可能是由于它们对生物膜屏障直接作用的结果。因此可认为,具改变细胞膜功能的药理活性的化合物,可以选作通过细胞膜吸收的药物的吸收促进剂。已知吩噻嗪类化合物能调节各种细胞膜的功能。为此,作者选用了两种在直肠内难以吸收的水溶性抗生素,即硫酸庆大霉素和头孢甲氧霉素钠作为目标药物,研究8种吩 It has been reported in the literature that surfactants, chelators, salicylates, anti-inflammatory drugs and basic amino acid salts can enhance the gastrointestinal permeability of a variety of compounds. Although the mechanism of action of these absorption enhancers is not clear, it is likely due to their direct effect on the biofilm barrier. Therefore, it is thought that the compounds having the pharmacological activity of changing the function of the cell membrane can be selected as the absorption enhancer of the drug absorbed through the cell membrane. Phenothiazine compounds are known to modulate the function of various cell membranes. To this end, the authors selected two kinds of water-soluble antibiotics difficult to absorb in the rectum, that is, gentamycin sulfate and cefmenoxime sodium as the target drug to study the eight kinds of phenols