我们初步建立从少量血清中提取神经节苷脂(GLS)的方法,并对比肝癌患者与正常人血清GLS高效薄板层析图谱。结果表明,前者血清GLS的GD_3组分明显增加,部分患者GM_2组分也显著增高。此改变与人肝癌组织GLS的变化基本一致,提示血清中出现的与肿瘤有关的GLS组分有可能成为诊断肿瘤的标记。 We initially established a method for the extraction of gangliosides (GLS) from a small amount of serum, and compared high-performance thin-layer chromatograms of serum GLS in liver cancer patients and normal individuals. The results showed that the serum GL3 fraction of the former significantly increased, and the GM2 fraction also increased significantly in some patients. This change is basically consistent with the change of human liver cancer tissue GLS, suggesting that the tumor-associated GLS components appearing in the serum may become markers for the diagnosis of tumors.