论文部分内容阅读
目的探讨妊娠合并血小板减少症的发病机制及围生期处理。方法对157例妊娠合并血小板减少患者的临床资料作回顾性研究。结果孕妇相关性血小板减少症(PAT)120例,特发性血小板减少性紫癜(ITP)15例,重度妊娠高血压综合征／先兆子痫(PIH)12例,肝病5例,系统性红斑狼疮(SLE)2例,病毒感染3例,剖宫产93例,占59．2％,阴道分娩64例,占(40．8)％,PAT和PIH患者产后42d血小板较产前差异均有显著性(P<0.05)。新生儿1例血小板为96×109/L,2例出现头皮血肿,其余血小板均正常。产后42d共有136例患者血小板恢复正常,8例ITP、1例SLE、1例肝病患者3个月后血小板仍未恢复正常。结论妊娠合并血小板减少症一般发生在妊娠晚期,以PAT最常见,孕期注意观察及给予相应治疗,产前适当提高血小板水平,可以减少并发症的发生。
Objective To investigate the pathogenesis and perinatal treatment of thrombocytopenia in pregnancy. Methods The clinical data of 157 pregnant women with thrombocytopenia were retrospectively reviewed. Results There were 120 cases of pregnancy related thrombocytopenia (PAT), 15 cases of idiopathic thrombocytopenic purpura (ITP), 12 cases of severe pregnancy induced hypertension / preeclampsia (PIH), 5 cases of liver disease, systemic lupus erythematosus (SLE) 2 cases, 3 cases of virus infection, 93 cases of cesarean section, accounting for 59.2%, 64 cases of vaginal delivery (40.8%), PAT and PIH patients 42d postpartum platelet prenatal differences were significant (P <0.05). One case of newborn platelets 96 × 109 / L, 2 cases of scalp hematoma, the remaining platelets were normal. Thirty-six days after delivery, platelet count returned to normal in 136 patients. Platelet count in 8 patients with ITP, 1 patient with SLE and 1 patient with liver disease did not return to normal after 3 months. Conclusions Pregnancy with thrombocytopenia usually occurs in the third trimester of pregnancy. The most common forms of PAT are pregnancy observed and given appropriate treatment. Prenatal appropriate increase of platelet levels can reduce the incidence of complications.