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目的:研究CD147在唾液腺腺样囊性癌(adenoid cystic carcinoma,ACC)中的表达及与腺样囊性癌临床病理特征、患者预后的关系。方法:采用免疫组化EnvisionTM法检测72例唾液腺腺样囊性癌组织和20例正常唾液腺组织CD147的表达,应用SPSS16.0软件包对实验数据进行统计学分析。结果:CD147在腺样囊性癌中表达阳性率为62.5%,显著高于正常唾液腺组(25.0%),P<0.01。CD147表达与腺样囊性癌大小、病理分型、临床分期、神经侵袭、血管侵袭及肿瘤转移显著相关(P<0.05),与患者性别、年龄及肿瘤复发无显著性相关(P>0.05)。单因素分析显示,CD147表达强阳性组累积生存率显著低于弱阳性及阴性表达组(P<0.0001)。多因素分析显示,CD147表达及肿瘤病理分型、血管侵袭、肿瘤转移是影响腺样囊性癌患者总生存期的独立预后因素(P<0.05)。结论:CD147的表达与腺样囊性癌临床病理特征密切相关,对腺样囊性癌诊断和预后评估有重要参考价值。
Objective: To investigate the expression of CD147 in adenoid cystic carcinoma (ACC) and its relationship with clinicopathological features and prognosis of adenoid cystic carcinoma. Methods: The expressions of CD147 in 72 cases of salivary adenoid cystic carcinoma and 20 cases of normal salivary gland were detected by EnvisionTM immunohistochemical method. The experimental data were analyzed by SPSS16.0 software package. Results: The positive rate of CD147 in adenoid cystic carcinoma was 62.5%, which was significantly higher than that in normal salivary gland (25.0%) (P <0.01). The expression of CD147 was significantly associated with the size, pathological type, clinical stage, invasion of nerve, invasion of blood vessels and metastasis of adenoid cystic carcinoma (P <0.05), but not with the gender, age and tumor recurrence (P> 0.05) . Univariate analysis showed that the cumulative survival rate of CD147 strongly positive group was significantly lower than that of weak positive group and negative expression group (P <0.0001). Multivariate analysis showed that CD147 expression and tumor pathological type, vascular invasion, tumor metastasis were independent prognostic factors (P <0.05) of total survival of patients with adenoid cystic carcinoma. Conclusions: The expression of CD147 is closely related to the clinicopathological features of adenoid cystic carcinoma, which has important reference value for the diagnosis and prognosis evaluation of adenoid cystic carcinoma.