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1989年以来,关于丙型肝炎病毒(HCV)的分子生物学、免疫学诊断和血清流行病学研究巳取得了许多成果,然而HCV感染的自然过程尚未阐明。为此,作者研究并仔细描述了HCV实验感染黑猩猩的过程。材料和方法8只西非黑猩猩,年龄5～10岁,体重20～50kg,先前均未接种过任何肝炎病毒、血源或血浆源材料。5只用美国国立卫生研究所提供的HCV F株(经3次黑猩猩传代)静脉接种;2只用急性期病人血清(源于日本Shimizu市)注射;另1只用受染黑猩猩的慢性
Since 1989, many achievements have been made in molecular biology, immunological diagnosis and serological epidemiology of Hepatitis C virus (HCV), however, the natural course of HCV infection has not been elucidated yet. To this end, the authors studied and carefully described the process of HCV infection in chimpanzees. MATERIALS AND METHODS Eight West African chimpanzees, aged 5 to 10 years and weighing 20 to 50 kg, had not been previously vaccinated with any hepatitis virus, blood or plasma source material. 5 were vaccinated with the HCV F strain (three chimpanzees) provided by the National Institutes of Health; two were injected with acute patient serum (Shimizu City, Japan); the other one was chronically infected with chimpanzees