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[摘要] 目的 探讨干扰素-γ诱导蛋白10(IP-10)在子痫前期(PE)孕妇血清和胎盘组织中的表达及意义。 方法 选择2015年1月~2017年2月61例PE孕妇,按照严重程度分为轻度PE组(33例)与重度PE组(28例);按照发病时间分为早发型PE组(24例)与晚发型PE组(37例),同期30例正常妊娠者为正常对照组,比较组间血清和胎盘组织中IP-10的表达情况。 结果 与正常对照组比较,轻度与重度PE组孕妇的血清IP-10水平、胎盘组织IP-10 蛋白表达量均明显升高(P均<0.05),且重度PE组均明显高于轻度PE组(P均<0.05),但早发型与晚发型PE组之间比较均无明显差异(P均>0.05)。 结论 PE孕妇血清和胎盘组织中IP-10的表达过度,可能通过介导炎症反应及抑制血管新生参与疾病的发生。
[关键词] 子痫前期;干扰素-γ诱导蛋白10;血清;胎盘
[中图分类号] R714.244 [文献标识码] A [文章编号] 1673-9701(2017)15-0012-03
[Abstract] Objective To investigate the expression and significance of interferon-γ inducible protein 10 in serum and placenta of pregnant women with preeclampsia. Methods 61 pregnant women with PE from Jan.2015 to Feb. 2017 were selected according to the severity, the patients were divided into mild PE group(33 cases) and severe PE group(n=28). According to the time of onset, the patients were divided into early onset PE group(n=24) and late onset PE group(n=37),and the normal control group was normal pregnancy with 30 cases. The expression of IP-10 in serum and placenta tissue was compared between groups. Results Compared with the normal control group, the levels of IP-10 in serum and placenta of the mild and severe PE group were significantly higher(P<0.05),and of the severe PE group were significantly higher than those of the mild PE group(P<0.05),while there were no significant difference between early onset and late onset PE group(P>0.05). Conclusion IP-10 in serum and placenta of pregnant women with PE are Overexpressed, which may be involved in the occurrence of disease by mediating inflammation and inhibiting angiogenesis.
[Key words] Reeclampsia; Interferon-γ inducible protein 10; Serum; Placenta
子癇前期(preeclampsia,PE)为妊娠期特有疾病,临床上表现为母体综合征可伴胎儿综合征,如蛋白尿、高血压脑病或伴多系统器官损伤等,或胎盘早剥、宫内窘迫等,尤其是重度子痫前期危害更甚,是导致我国孕产妇死亡的第2大原因[1,2]。PE的病因及发病机制比较复杂,目前认为可能的致病因素有螺旋动脉异常变形、上皮细胞功能失常、血管新生抑制、慢性子宫胎盘缺血、Th 1/Th 2型细胞因子紊乱、血管内炎症等[3]。干扰素-γ诱导蛋白10(interferon-γ inducible protein 10,IP-10)是新近发现的由干扰素-γ诱导产生的一种趋化因子,既往研究已证明,IP-10能通过介导 Th1 型炎症反应参与病毒性肝炎、系统性红斑狼疮、类风湿性关节炎、肺结核、动脉粥样硬化等疾病,此外IP-10也是一种血管新生抑制因子[4,5]。动物实验发现,PE孕鼠肝肾、子宫等组织中 IP-10的表达增高[6],引起了学者的关注。本研究分析IP-10在PE孕妇血清和胎盘组织中的表达变化,为 IP-10在PE发病中的作用机制提供参考。
1资料与方法
1.1一般资料
抽取2015年1月~2017年2月61例PE孕妇,年龄22~33岁,平均(26.56±2.38)岁,其中轻度33例,重度28例;早发型(发病孕周<34周)24例,晚发型(发病孕周>34周)37例。选择同期正常妊娠者30例,年龄21~30岁,平均(25.98±3.12)岁。入院时采集清晨空腹静脉血2 mL分离血清,分娩后即刻留取胎盘母体面组织,保存待检,两组间基本资料间比较差异无统计学意义(P>0.05),具有可比性。
纳入标准:①患者诊断标准符合《妇产科学》(第 7 版)[7];②可以收集到患者完整检查和治疗以及病史资料等;③研究经过医院伦理委员会批准,患者知情同意等;排除标准:①入选对象均为单胎妊娠;②伴有其他妊娠合并症及并发症者;③患有意识障碍性疾病,无法配合研究者;④依从性差,或拒绝参加研究者。 1.2 方法
1.2.1 血清IP-10水平的检测 采取双抗体夹心 ELISA法,按试剂盒(美国 R
[关键词] 子痫前期;干扰素-γ诱导蛋白10;血清;胎盘
[中图分类号] R714.244 [文献标识码] A [文章编号] 1673-9701(2017)15-0012-03
[Abstract] Objective To investigate the expression and significance of interferon-γ inducible protein 10 in serum and placenta of pregnant women with preeclampsia. Methods 61 pregnant women with PE from Jan.2015 to Feb. 2017 were selected according to the severity, the patients were divided into mild PE group(33 cases) and severe PE group(n=28). According to the time of onset, the patients were divided into early onset PE group(n=24) and late onset PE group(n=37),and the normal control group was normal pregnancy with 30 cases. The expression of IP-10 in serum and placenta tissue was compared between groups. Results Compared with the normal control group, the levels of IP-10 in serum and placenta of the mild and severe PE group were significantly higher(P<0.05),and of the severe PE group were significantly higher than those of the mild PE group(P<0.05),while there were no significant difference between early onset and late onset PE group(P>0.05). Conclusion IP-10 in serum and placenta of pregnant women with PE are Overexpressed, which may be involved in the occurrence of disease by mediating inflammation and inhibiting angiogenesis.
[Key words] Reeclampsia; Interferon-γ inducible protein 10; Serum; Placenta
子癇前期(preeclampsia,PE)为妊娠期特有疾病,临床上表现为母体综合征可伴胎儿综合征,如蛋白尿、高血压脑病或伴多系统器官损伤等,或胎盘早剥、宫内窘迫等,尤其是重度子痫前期危害更甚,是导致我国孕产妇死亡的第2大原因[1,2]。PE的病因及发病机制比较复杂,目前认为可能的致病因素有螺旋动脉异常变形、上皮细胞功能失常、血管新生抑制、慢性子宫胎盘缺血、Th 1/Th 2型细胞因子紊乱、血管内炎症等[3]。干扰素-γ诱导蛋白10(interferon-γ inducible protein 10,IP-10)是新近发现的由干扰素-γ诱导产生的一种趋化因子,既往研究已证明,IP-10能通过介导 Th1 型炎症反应参与病毒性肝炎、系统性红斑狼疮、类风湿性关节炎、肺结核、动脉粥样硬化等疾病,此外IP-10也是一种血管新生抑制因子[4,5]。动物实验发现,PE孕鼠肝肾、子宫等组织中 IP-10的表达增高[6],引起了学者的关注。本研究分析IP-10在PE孕妇血清和胎盘组织中的表达变化,为 IP-10在PE发病中的作用机制提供参考。
1资料与方法
1.1一般资料
抽取2015年1月~2017年2月61例PE孕妇,年龄22~33岁,平均(26.56±2.38)岁,其中轻度33例,重度28例;早发型(发病孕周<34周)24例,晚发型(发病孕周>34周)37例。选择同期正常妊娠者30例,年龄21~30岁,平均(25.98±3.12)岁。入院时采集清晨空腹静脉血2 mL分离血清,分娩后即刻留取胎盘母体面组织,保存待检,两组间基本资料间比较差异无统计学意义(P>0.05),具有可比性。
纳入标准:①患者诊断标准符合《妇产科学》(第 7 版)[7];②可以收集到患者完整检查和治疗以及病史资料等;③研究经过医院伦理委员会批准,患者知情同意等;排除标准:①入选对象均为单胎妊娠;②伴有其他妊娠合并症及并发症者;③患有意识障碍性疾病,无法配合研究者;④依从性差,或拒绝参加研究者。 1.2 方法
1.2.1 血清IP-10水平的检测 采取双抗体夹心 ELISA法,按试剂盒(美国 R