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实验大白鼠分三组：肝硬化组给以四氯化碳（ＣＣｌ４）等复合因素；给药组除ＣＣｌ４等复合因素外，给以赤栀黄煎剂灌胃４１天；正常组给予一般饮食及饮用水。结果给药组与肝硬化组相比，肝硬化形成率明显降低，肝小叶损伤区域明显缩小，肝细胞中脂滴减少，细胞核增大，ＲＮＡ及核仁增多，糖原恢复，ＳＤＨ、Ｇ－６－Ｐａｓｅ活性增强。表明赤栀黄合剂能减轻ＣＣｌ４等复合因素引起的肝硬变，并对其机理进行了讨论。
The experimental rats were divided into three groups: the cirrhosis group was given compound factors such as carbon tetrachloride (CCl4); in addition to CCl4 and other compound factors, the administration group was given gavage of Astragalus membranaceus for 41 days; the normal group was given a general diet. And drinking water. Results Compared with the cirrhosis group, the cirrhosis formation rate was significantly lower in the administration group, the hepatic lobule damage area was significantly reduced, the lipid droplets in the hepatocytes decreased, the nuclei increased, the RNA and nucleoli increased, and the glycogen recovered. SDH, G- 6-Pase activity is enhanced. It was shown that Chishao Huanghe Mixture can reduce the liver cirrhosis caused by CCl4 and other complex factors, and its mechanism was discussed.