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利用酶联免疫吸附法（ＥＬＩＳＡ）检测了１３５例恶性肿瘤患者血清中层粘蛋白（Ｌａｍｉｎｉｎ，ＬＮ）的含量，比较了良恶性肿瘤及健康成人血清ＬＮ的差别，对ＬＮ在癌变中的机制进行了初步探讨。结果表明，所有恶性肿瘤患者血清ＬＮ值均高于健康对照（Ｐ＜０．００１），并且高于良性肿瘤患者（Ｐ＜０．００１），良性肿瘤和健康组之间没有差别（Ｐ＞０．０５）。以正常人ＬＮ值上限为界，恶性肿瘤阳性分布率为７４．８％，良性肿瘤１３％，正常人假阳性为８．５％。提示ＬＮ可作为辅助诊断恶性肿瘤、区分肿瘤良恶性的一项重要参考指标。
The levels of laminin (LN) in serum of 135 patients with malignant tumors were detected by enzyme-linked immunosorbent assay (ELISA). The differences in serum LN between benign and malignant tumors and healthy adults were compared. The mechanism of LN in carcinogenesis was studied. Preliminary discussion. The results showed that the serum LN values of all patients with malignant tumors were higher than those of healthy controls (P<0.001) and were higher than those of benign tumor patients (P<0.001). There was no difference between benign tumors and healthy patients (P>0). .05). With the upper limit of normal LN value as the boundary, the positive rate of malignant tumors was 74.8%, benign tumors were 13%, and normal people had false positives of 8.5%. It is suggested that LN can be used as an important reference index for the diagnosis of malignant tumors and differentiation of benign and malignant tumors.