“局部未能切除”一词的意思是原发病灶不能手术切除,与是否有转移无关。局部未能切除胃癌患者的预后不好,尽管使用各种辅助治疗,生存期的延长很短。作者所在的日本国立癌中心医院1968～1974年有231例胃癌局部未能切除,192例最终因癌死亡,除40例因付作用停用化疗或拒治外,有107例进行了化疗、46例未进行化疗。因为化疗的进展,不可避免使用较多的药物方案。主要方案是FAMT(5-Fu、CTX、MMC 和色霉素A_3即CHUM)、Ftorafur、5-Fu 动脉灌注。FAMT 给药方法:5-Fu 静脉注射,10mg/kg/天,CTX4mg/kg/天,MMC0.04mg/kg/天,CHRM0.01mg/kg/天,每周二次,用四周。Ftorafur 按40kg 体重口服 The term “local failure to excise” means that the primary lesion cannot be surgically removed and is not associated with metastasis. The prognosis of patients who have not been able to remove gastric cancer locally is not good. In spite of the use of various adjuvant treatments, the extension of survival is short. At the National Cancer Center Hospital of the author’s from 1968 to 1974, 231 cases of gastric cancer were not partially resected, and 192 cases eventually died of cancer. In addition to 40 cases of chemotherapy or reluctance to stop treatment, 107 cases were treated with chemotherapy. Cases were not treated with chemotherapy. Because of the progress of chemotherapy, it is inevitable to use more drug programs. The main protocol is FAMT (5-Fu, CTX, MMC, and Chromatin A_3, ie CHUM), Ftorafur, and 5-Fu arterial perfusion. FAMT administration method: intravenous injection of 5-Fu, 10 mg/kg/day, CTX 4 mg/kg/day, MMC 0.04 mg/kg/day, CHRM 0.01 mg/kg/day, twice per week for four weeks. Ftorafur Oral by 40kg body weight