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依布硒琳（Ｅｂｓ）是一种具有过氧化物酶样活性的含硒有机化合物，本文以阿霉素处理的ＢＡＬＢ／ｃ小鼠为模型研究了Ｅｂｓ的保护作用．结果表明Ｅｂｓ能够减少阿霉素诱发的心肌脂质过氧化物的形成并提高机体谷胱甘肽过氧化物酶与脂质过氧化物的比值，防止阿霉素对心脏脂质过氧化损伤的毒性；同时测定血清肌酸激酶和谷草转氨酶活性，发现Ｅｂｓ也能保护组织免受阿霉素的损伤．
Ebselen (Ebs) is a kind of peroxidase-like selenium-containing organic compounds. In this paper, the protective effect of Ebs was studied using doxorubicin-treated BALB / c mice as a model. The results show that Ebs can reduce doxorubicin-induced myocardial lipid peroxides formation and increase the body’s glutathione peroxidase and lipid peroxidation ratio, to prevent doxorubicin on lipid peroxidation injury in the heart Toxicity; Simultaneous determination of serum creatine kinase and aspartate aminotransferase activity and found that Ebs can also protect the tissue from doxorubicin damage.