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苯妥英钠是临床最常用和最有效的抗癫痫药物之一,其毒副作用已为大家所熟知,唯其所致全部眼外肌麻痹罕为人知。国外已有报导,国内未见文献记载。现将所见1例报导如下。陈月华,女,32岁,已婚,出生和发育正常,12岁时从楼梯上跌下,当时昏迷20分许,伴呕吐,嗣后虽不适,一月后开始有发作性四肢抽搐,意识丧失、尿失禁,每次数分钟,多时一天达四次,先后服用Luminal,Phenytoin,Valproic acidt,Tegretol,等均未见显效。1986年7月12日癫痫频发除服用tegretol 0.1tid,mysolin 0.25tid外, 家属自行增加phenytoin 0.3tid。7天后出现讲话口齿不清、复视,行走不稳并有高热39℃以
Phenytoin sodium is one of the most commonly used and most effective anti-epileptic drugs in clinical practice. Its side effects have been well known to all. Only a few of them are known to cause paralysis of all extraocular muscles. Abroad has been reported, there is no domestic documentation. Now we see a case reported as follows. Chen Yuehua, female, 32 years old, married, born and developed normally. She fell from the stairs when she was 12 years old. At that time she was unconscious for 20 minutes with vomiting. Although later she was ill, episodes of seizures and loss of consciousness started after January. Urinary incontinence, every few minutes, many times a day up to four times, has taken Luminal, Phenytoin, Valproic acid, Tegretol, and so were no effective. July 12, 1986 Epilepsy Frequent addition to taking tegretol 0.1tid, mysolin 0.25tid, the family members to increase phenytoin 0.3tid. 7 days after the speech appeared speechless, diplopia, unstable walking and high fever 39 ℃