目的:研制盐酸利多卡因温敏凝胶并考察其释药机制。方法:以泊洛沙姆P407为凝胶材料,以泊洛沙姆P188、PEG6000调节胶凝温度,并采用正交试验筛选处方,采用数学模型拟合释放曲线。结果:盐酸利多卡因温敏凝胶在32～33℃胶凝,释药行为符合Higuchi方程。结论:盐酸利多卡因温敏凝胶处方设计合理,可进一步研究开发。 Objective: To develop lidocaine hydrochloride thermosensitive gel and study its mechanism of drug release. Methods: Poloxamer P407 was used as the gel material, poloxamer P188 and PEG6000 were used to adjust the gelation temperature. The orthogonal test was used to select the prescription and the release curve was fitted by mathematical model. Results: The lidocaine hydrochloride gels were gelled at 32-33 ℃, and the drug release behavior was consistent with the Higuchi equation. Conclusion: The formulation of lidocaine hydrochloride thermosensitive gel is reasonable and can be further studied.