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目的 探讨治疗直肠癌简单 ,安全有效的辅助化疗方法。方法 113例直肠癌患者随机分为试验组 (T组 ) :术前 5 Fu 2 5 0～ 5 0 0mg ,保留灌肠 ,每晚 1次 ,共 10d。术后 1周 ,给予 5 Fu 5 0 0mg/M2 ,CF(甲酰四氢叶酸钙 ) 30mg或 30 0mg/M2 ,静注 ,每日 1次 ,共 5d ,以后每月 1次 ,共 5～ 6次 ;对照组 (C组 ) :术前单用 5 Fu 5 0 0mg/M2 ,静注 ,每日 1次 ,共 5d ,术后 1周再用 5 Fu5 0 0mg/M2 ,静注 ,每日 1次 ,共 5d ,以后每月 1次 ,共 5～ 6次。随访 5年 ,完全随访率 6 9.9%。结果 两组在 3年生存率 ,术前血象改变无显著性差异 ,而 5年生存率 ,术后复发率和术后感染率有显著性差异。结论 术前 5 Fu保留灌肠和术后 5 Fu/CF化疗可提高 5年生存率和降低复发率
Objective To explore the simple, safe and effective adjuvant chemotherapy for rectal cancer. Methods 113 patients with rectal cancer were randomly divided into experimental group (T group): Preoperative 5 Fu 250-500mg, retention enema, 1 night, for 10 days. One week after surgery, 5 Fu 500 mg/M2, CF (formyl calcium tetrahydrofolate) 30 mg or 300 mg/M2, intravenously, once daily for 5 days, then once a month, total 5 to 5 6 times; control group (C group): 5 Fu 500 mg/M2 alone before operation, intravenously, once daily for 5 days, and 5 Fu 500 mg/M2 for 1 week after surgery, intravenously Once a day, a total of 5d, then once a month, a total of 5 to 6 times. Follow-up of 5 years, complete follow-up rate of 6.9%. Results In the three-year survival rate of the two groups, there was no significant difference in preoperative blood changes, but the 5-year survival rate, postoperative recurrence rate, and postoperative infection rate were significantly different. Conclusion Preoperative 5 Fu retention enema and postoperative 5 Fu/CF chemotherapy can improve 5-year survival rate and reduce recurrence rate