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缬沙坦(Valsartan)是一种新的血管紧张素Ⅱ(Ang Ⅱ)受体拮抗剂。其特点是降压效果平稳,服用简单(每日1次),无首剂低血压反应。它不抑制缓激肽降解,因而没有ACE抑制剂类引起的咳嗽和血管神经性水肿副作用。与洛沙坦一起,目前占据抗高血压药物市场的有利地位。1 药理学 缬沙坦属于非肽类AT_1受体拮抗剂。它通过选择性、特异性地阻断Ang Ⅱ与AT_1受体的结合而产生有效的降压效应。缬
Valsartan is a new angiotensin Ⅱ (Ang Ⅱ) receptor antagonist. It is characterized by stable antihypertensive effect, taking a simple (1 day), no first dose of hypotensive reactions. It does not inhibit bradykinin degradation and therefore has no side effects of cough and angioedema caused by ACE inhibitors. Together with losartan, it now holds a favorable position in the antihypertensive drug market. Pharmacology Valsartan is a non-peptide AT1 receptor antagonist. It produces an effective antihypertensive effect by selectively and specifically blocking the binding of Ang II to the AT 1 receptor. Valerian