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由于认识水平的提高和诊断技术的改进,有关胰高糖素瘤的文献已相继报道。本文报告一例以坏死溶解和迁移性红斑为特征的恶性胰高糖素瘤。患者女性,57岁,15个月以来上肢、躯干和臀部出现慢性红斑性皮疹,她有糖尿和高血压史二年,在三年内体重下降7公斤。入院时体检发现躯干和臀部有环形红斑,皮肤活检显示表皮浅层呈大泡状破裂,伴有细胞内和细胞间水肿,真皮浅层显示淋巴细胞性脉管炎。实验室检查提示有常细胞性常色素性贫血,轻度糖
As a result of the increase in the level of understanding and the improvement of diagnostic techniques, the literature on glucagonoma has been reported in succession. This article reports a case of malignant glucagonoma characterized by necrotic lysis and migratory erythema. The female patient, 57 years old, had a chronic erythematous rash on the upper limbs, trunk and hips for 15 months. She had a history of diabetes and hypertension for two years and she lost 7 kg in three years. Physical examination revealed a ring-shaped erythema on the trunk and buttocks. Skin biopsy revealed a macrobubble-like rupture of the epidermis with intracellular and intercellular edema. The superficial dermis showed lymphocytic vasculitis. Laboratory tests suggest that often cellular abnormal pigmentary anemia, light sugar