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目的探讨广西地区新生儿先天性甲状腺功能减退症(CH)筛查检出率及其与新生儿出生体重、孕周的关系。方法 2014年广西壮族自治区新生儿疾病筛查中心共筛查258 098名新生儿,出生后72 h采新生儿足跟血制作滤纸片标本,用时间分辨荧光免疫分析法检测血斑中促甲状腺激素(TSH)浓度,并将初筛值大于筛查切值者召回进行确诊检查。结果确诊CH患儿122例,发病率为1∶2 116。单一性早产儿或单一性低体重儿CH发病率和其他对照组新生儿比较差异均无统计学意义(P>0.05),只有在早产和低体重同时存在的新生儿中CH发病率会升高,发病率为1∶657,远高于其他新生儿(P<0.05)。结论早产低体重儿各方面系统功能不健全可能是造成CH高发病率的原因,建立完善的新生儿疾病筛查质量保障体系至关重要。
Objective To investigate the detection rate of congenital hypothyroidism (CH) screening in Guangxi and its relationship with newborn birth weight and gestational age. Methods A total of 258 098 newborns were screened in the Newborns Disease Screening Center of Guangxi Zhuang Autonomous Region in 2014. Blood samples were taken from the heel of the newborn fetus at 72 h after birth. TUNEL assay was used to detect thyrotropin (TSH) concentration, and screening the initial screening value is greater than the cut-off value of the recall for diagnosis. Results Confirmed 122 cases of CH children, the incidence was 1: 2 116. There was no significant difference in incidence of CH among single-sex preterm infants or single low-birth-weight infants and newborns of other control groups (P> 0.05). CH incidence was only increased in neonates with preterm birth and low birth weight , The incidence of 1:657, much higher than other newborns (P <0.05). Conclusions Inadequate systemic function in all aspects of preterm low birth weight infants may be the reason for the high morbidity of CH. It is of vital importance to establish a sound quality assurance system for screening neonatal diseases.