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目的 :调查炎症性肠病患者睡眠质量并分析其影响因素。方法 :采用匹兹堡睡眠质量指数量表(Pittsburgh Quality Sleep Index,PSQI)、疾病活动指数等工具收集炎症性肠病专科门诊就诊及肛肠科、消化科住院的120例患者资料。结果 :患者的睡眠障碍发生率高达55.8%(溃疡性结肠炎:47.6%,克罗恩病:64.9%)、PSQI平均(8.07±2.91)分,明显高于健康人群(P<0.05),其中主观睡眠质量(1.54±0.66)分、入睡时间(1.62±0.74)分、睡眠时间(1.16±0.71)分、睡眠效率(0.89±0.63)分、睡眠障碍(1.10±0.42)分、催眠药物(0.17±0.37)分、日间功能紊乱(1.59±0.76)分。经Stepwise多元回归法明确疾病活动期、无业(学习)、女性、接受激素类药物治疗是影响炎症性肠病患者睡眠质量的重要因素。结论 :炎症性肠病患者的睡眠质量低,与疾病活动性、工作/学习状态、性别及目前用药方案有关,临床应重视其中的关联性,将患者睡眠质量的评估纳入疾病管理方案中。
Objective: To investigate the quality of sleep in patients with inflammatory bowel disease and analyze its influencing factors. Methods: A total of 120 patients were enrolled in the specialist clinic of IBD and hospitalized in the department of anorectal and gastroenterology with the Pittsburgh Sleep Quality Index (PSQI) and disease activity index. Results: The incidence of sleep disorders was 55.8% (ulcerative colitis: 47.6%, Crohn’s disease: 64.9%) and PSQI was (8.07 ± 2.91), which was significantly higher than that of healthy people (P <0.05) Subjective sleep quality (1.54 ± 0.66), sleep time (1.62 ± 0.74), sleep time (1.16 ± 0.71), sleep efficiency (0.89 ± 0.63), sleep disturbance (1.10 ± 0.42) ± 0.37) points, daytime dysfunction (1.59 ± 0.76) points. Stepwise multiple regression method to clear the disease activity, unemployed (learning), women, receiving hormone therapy is an important factor affecting the quality of sleep in patients with inflammatory bowel disease. CONCLUSIONS: The poor quality of sleep in patients with inflammatory bowel disease is related to disease activity, work / study status, gender and the current medication regimen. Clinical relevance should be attached to this and the assessment of sleep quality should be included in the disease management plan.