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目的阐明幽门螺杆菌在胃癌前病变中的感染情况。方法应用ＣＬＯ－ｔｅｓｔ、组织学和分子生物学方法联合检测患者 胃粘膜活检标本中幽门螺杆菌感染。结果不典型增生、肠化生组织中Ｈｐ的检出率显著高于正常胃粘膜。Ｈｐ感染和患者年 龄、性别无关。结论Ｈｐ可能在从浅表性胃炎→肠化生→不典型增生→胃癌的发生过程中起一定作用。
Objective To elucidate the infection of Helicobacter pylori in precancerous lesions. Methods Helicobacter pylori infection in gastric mucosa biopsy specimens was detected by CLO-test, histology and molecular biology methods. Results The detection rate of Hp in atypical hyperplasia and intestinal metaplasia was significantly higher than that in normal gastric mucosa. Hp infection is not related to the age or sex of the patient. Conclusion Hp may play a role in the development of superficial gastritis, intestinal metaplasia, atypical hyperplasia, and gastric cancer.