【摘 要】
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Dear Editor,In eukaryotic cells,the endoplasmic reticulum (ER) is a continuous membrane system with interconnected tubules and sheets.The formation of a typical
【机 构】
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Tianjin Key Laboratory of Protein Sciences, Department of Genetics and Cell Biology, College of Life
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Dear Editor,In eukaryotic cells,the endoplasmic reticulum (ER) is a continuous membrane system with interconnected tubules and sheets.The formation of a typical network requires constant fusion between ER membranes.A class of membrane-bound dynamin-like GTPases called atlastins (ATLs)has been identified as mediating ER fusion (Hu et al.,2009;Orso et al.,2009).The depletion of ATL results in an unbranched ER phenotype (Rismanchi et al.,2008;Hu et al.,2009),indicating a lack of interconnections among ER membranes.Antibodies against ATL block ER network formation in vitro when using Xenopus egg membrane extracts (Hu et al.,2009).The fusogenic activity of ATL is also observed when purified full-length Drosophila ATL is reconstituted into proteoliposomes,with the fusion of these vesicles detected in vitro (Orso et al.,2009;Liu et al.,2012).
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