本工作研究了油酸钠的细胞保护作用及其作用机制。油酸钠对消炎痛引起的小鼠胃粘膜损伤有明显的保护作用,并且有剂量—效应关系。这种作用不是由于抑制胃酸分泌或被吸收入血所引起的,也不是通过交感神经和副交感神经传递的。油酸钠的主要作用部位在小肠,因此,它对胃粘膜的保护作用很可能是通过刺激小肠释放多种胃肠激素的综合作用而实现的;增加胃粘液分泌是其保护机制之一。 This work studied the cell protection of sodium oleate and its mechanism of action. Sodium oleate has obvious protective effect on mouse gastric mucosal injury induced by indomethacin, and has a dose-effect relationship. This effect is not caused by the inhibition of gastric acid secretion or absorption into the bloodstream, nor by the sympathetic and parasympathetic nerves. The main role of sodium oleate in the small intestine, therefore, its protective effect on gastric mucosa is likely to stimulate the small intestine to release a variety of gastrointestinal hormones and the combined effect achieved; increase gastric mucus secretion is one of the protective mechanisms.