目的分析2009~2013年乌鲁木齐市手足口病流行特征及病原构成变化,为制定防控措施提供科学依据。方法通过疾病监测管理系统收集2009~2013年乌鲁木齐市全年手足口病发病资料,采用描述性流行病学方法分析手足口病三间分布特征,采集手足口病病例的粪便、咽拭子及疱疹液标本进行病原学检测。结果 2009~2013年乌鲁木齐市共报告手足口病病例11 152例,年平均报告发病率为75.89/10万,全年均有病例报告,6~7月份为手足口病高发季节;男性高于女性,男女比例为1.52:1;发病年龄主要集中在0~5岁,占总病例数的88.62%,以托幼儿童和散居儿童为主;中心城区手足口病发病率高于周边城区。2009~2013年共检测2 061例手足口病标本,检出阳性标本1 699例,阳性检出率为82.43%。阳性标本中,EV71、Cox A16及其它肠道病毒的构成比分别为32.84%、44.61%和22.54%,结论 2009~2013乌鲁木齐市手足口病发病呈波浪式上升趋势;手足口病主要病原体构成比有变化。 Objective To analyze the epidemiological characteristics and pathogenic changes of HFMD in Urumqi from 2009 to 2013 and provide a scientific basis for making prevention and control measures. Methods The data of hand-foot-mouth disease in Urumqi from 2009 to 2013 were collected through disease surveillance and management system. The distribution of hand-foot-mouth disease was analyzed by descriptive epidemiology. The faeces, throat swabs and herpes Liquid specimens for etiological testing. Results A total of 11 152 HFMD cases were reported in Urumqi from 2009 to 2013, with an annual average incidence of 75.89 per 100 000 cases. Cases were reported throughout the year, and the HFMD season was from June to July. The male was higher than the female , The male-female ratio was 1.52: 1. The age of onset was mainly between 0 and 5 years old, accounting for 88.62% of the total number of cases, mainly children in kindergartens and children in diaspora. The incidence rate of hand-foot-mouth disease in downtown was higher than that in the surrounding urban areas. A total of 2 061 cases of hand, foot and mouth disease were detected from 2009 to 2013. A total of 1 699 positive samples were detected, the positive rate was 82.43%. The positive rates of EV71, Cox A16 and other enteroviruses were 32.84%, 44.61% and 22.54%, respectively. Conclusion The incidence of HFMD in Urumqi from 2009 to 2013 showed a wave-like upward trend. The composition ratio of major pathogen of HFMD Change.