论文部分内容阅读
目的:探讨坤泰胶囊联合雌二醇片/雌二醇地屈孕酮片复合包装（商品名：芬吗通）治疗围绝经期综合征患者效果观察及对性激素、抗缪勒管激素（AMH）和骨密度的影响。方法:选择宁波开发区中心医院2018年1月至2019年1月收治的围绝经期综合征患者118例，依据随机数字表法分为对照组与观察组，每组59例。对照组给予芬吗通治疗，观察组给予坤泰胶囊联合芬吗通治疗。两组均以28 d为1个周期，连续服用6个周期。比较两组治疗前后Kupperman绝经指数（KMI）评分、性激素、AMH和骨密度的变化。结果:观察组治疗后KMI评分低于对照组[（6.27 ± 1.42）分比（9.89 ± 1.74）分]（n t=12.381，n P<0.05）。观察组治疗后血清雌二醇（En 2）水平高于对照组[（195.48 ± 12.43）pmol/L比（165.65 ± 10.76）pmol/L]，而血清黄体生成素（LH）和卵泡刺激素（FSH）低于对照组[（35.46 ± 1.76）U/L比（39.92 ± 2.13）U/L、（36.57 ± 2.34）U/L比（40.38 ± 1.89）U/L]，差异均有统计学意义（n P<0.05）。观察组治疗后血清AMH水平高于对照组[（3.24 ± 0.68）μg/L比（1.97 ± 0.57）μg/L]（n t=10.994，n P<0.05）。观察组治疗后骨密度高于对照组[（0.87 ± 0.13）g/cmn 2比（0.71 ± 0.07）g/cmn 2]（n t=8.324，n P<0.05）。n 结论:坤泰胶囊联合芬吗通治疗围绝经期综合征效果良好，可改善性激素水平，提高AMH水平，增加骨密度。“,”Objective:To investigate the effect of Kuntai capsule combined with fenmotong in the treatment of perimenopausal syndrome and its effects on sex hormone, anti-Mullerian hormone (AMH) and bone mineral density (BMD).Methods:One hundred and eighteen patients with perimenopausal syndrome admitted to Ningbo Development Zone Central Hospital from January 2018 to January 2019 were randomly divided into observation group (59 cases) and control group (59 cases). The patients in the control group were treated with Fenmotong, while the patients in the observation group were treated with Kuntai capsule on the basis of the control group. Both groups took 28 d as a cycle for 6 consecutive cycles. The changes of Kupperman menopausal index (KMI), sex hormone, AMH and bone mineral density before and after treatment were compared between the two groups.Results:The KMI score of the observation group was lower than that of the control group [(6.27 ± 1.42) scores vs. (9.89 ± 1.74) scores](n t=12.381, n P<0.05). The level of serum estradiol (En 2) in the observation group was higher than that in the control group [(195.48 ± 12.43) pmol/L vs. (165.65 ± 10.76) pmol/L], while the levels of serum luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in the observation group were lower than those in the control group [(35.46 ± 1.76) U/L vs. (39.92 ± 2.13) U/L, (36.57 ± 2.34) U/L vs. (40.38 ± 1.89)U/L](n P<0.05). The serum AMH level of the observation group was higher than that of the control group [(3.24 ± 0.68) μg/L vs. (1.97 ± 0.57) μg/L] (n t=10.994, n P<0.05). The BMD of the observation group was higher than that of the control group [(0.87 ± 0.13) g/cmn 2 vs. (0.71 ± 0.07) g/cmn 2](n t=8.324, n P<0.05).n Conclusions:Kuntai capsule combined with Fenmotong has a good effect in the treatment of perimenopausal syndrome. It can improve the level of sex hormones, AMH and bone mineral density.