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目的为探讨江门地区围产期妇女B族链球菌(GBS)的分布以及耐药情况,指导临床进行早期预防和治疗,降低围产期妇女和新生儿GBS感染的发生率。方法对2 230例妊娠35~37周的孕妇进行GBS监测,分析围产期妇女GBS的检测率和耐药率。结果 2 230例孕妇中GBS检测率为10.1%(226/2 230);阴道部位GBS的检出率为8.78%(196/2 230),直肠部位GBS的检出率为5.07%(113/2 230),阴道和直肠部位同时出现GBS的检出率为3.85%(86/2 230);GBS的耐药率分别为青霉素0.9%、氨苄西林0.9%、克林霉素59.2%、红霉素74.3%、头孢曲松0.0%、万古霉素0.0%。结论阴道和直肠均为孕妇携带GBS的部位,建议对孕妇进行GBS监测时应选取阴道和直肠部位同时送检以提高GBS的检出率;GBS阳性的孕妇应进行产时预防性治疗,青霉素和氨苄西林是预防GBS感染的首选药物。
Objective To investigate the distribution and drug resistance of Streptococcus group B Streptococcus (Streptococcus pneumoniae) in perinatal women in Jiangmen area, and to guide the early prevention and treatment in clinical practice and to reduce the incidence of GBS infection in perinatal women and newborns. Methods A total of 2 230 pregnant women with gestational age of 35-37 weeks underwent GBS monitoring. The detection rate and resistance rate of GBS in perinatal women were analyzed. Results The detection rate of GBS in 2 230 pregnant women was 10.1% (226/2 230). The detection rate of GBS in vaginal part was 8.78% (196/2 230) and that of rectal part was 5.07% (113/2 230). The detection rate of simultaneous GBS in the vagina and rectum was 3.85% (86/2 230). The drug resistance rates of GBS were 0.9% of penicillin, 0.9% of ampicillin, 59.2% of clindamycin, 74.3%, ceftriaxone 0.0%, vancomycin 0.0%. Conclusions Both vaginal and rectum are the sites of GBS for pregnant women. It is suggested that vaginal and rectal sites should be selected for simultaneous detection of GBS in pregnant women, so as to improve the detection rate of GBS. Pregnant women with GBS should be given prophylactic treatment during birth and penicillin and Ampicillin is the first choice to prevent GBS infection.