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蛋白质、核酸、病毒等物质的高灵敏度定量检测在疾病诊断、医学研究中起到重要作用。硅纳米线场效应管(SiNWs-FET)生物传感器有望在蛋白质和其它分子的非标记、快速实时响应、超高灵敏检测中成为极有价值的方法之一。本文介绍了硅纳米线场效应管生物传感器的工作原理并总结其在医学中的应用进展,讨论了提高硅纳米线生物传感器灵敏度的方法及目前所面临的挑战,并展望了硅纳米线场效应管生物传感器的发展前景。
High-sensitivity quantitative detection of proteins, nucleic acids, viruses and other substances play an important role in the diagnosis of diseases and medical research. Silicon Nanowire Field-Effect Transistors (SiNWs-FETs) Biosensors are expected to be one of the most valuable methods for unlabeled, fast real-time response, and ultra-sensitive detection of proteins and other molecules. This paper introduces the working principle of the silicon nanowire FET biosensor and summarizes its application in medicine. The methods to improve the sensitivity of the silicon nanowire biosensor and the current challenges are discussed. Finally, the silicon nanowire field effect Tube biosensor development prospects.