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商品肝素已广泛应用于临床。其盐除肝素钠外,尚有肝素钙以及钾盐和镁盐。据报道,肝素钠和肝素钙的生物活性是一致的,高浓度肝素钙皮下注射对治疗血栓栓塞、急性血液高凝状态性疾病有效,且肝素钙皮下注射所致局部疼痛、不适和瘀斑比肝素钠为轻。目前肝素钙已受到医学界的关注,日本以及欧洲的许多国家已进行生产与应用。本文介绍用离子交换法生产肝素钙,其制备工艺如下:
Commodity heparin has been widely used in clinical. In addition to its salt of heparin sodium, there are heparin and potassium and magnesium salts. It has been reported that the biological activity of heparin sodium and heparin calcium is consistent with the high concentration of heparin calcium subcutaneous injection for the treatment of thromboembolism, acute hypercoagulable state disease effective and heparin calcium subcutaneous injection of local pain, discomfort and ecchymosis ratio Heparin sodium is light. Heparin calcium has now been the medical profession’s attention, Japan and many European countries have been producing and application. This article describes the use of ion exchange production of heparin, the preparation process is as follows: