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以听源性惊厥易感大鼠为模型 ,用免疫细胞化学结合动物行为观察的方法 ,研究了从癫痫点燃后 30 m in至 3d 8个时间点的延髓内脏带内星形胶质细胞特异性标识物胶质原纤维酸性蛋白的分布变化。结果显示 :癫痫点燃后 1h细小型星形胶质细胞数量开始增多 ,尤以孤束核及软膜附近明显 ;6 h后延髓内脏带各区胶质原纤维酸性蛋白阳性细胞均增多 ,以延髓内脏带背内侧区及腹外侧区较为密集 ,中间带状区相对较少 ;1d后肥大型星形胶质细胞开始增多 ;3d后肥大型细胞出现肿胀、变形。此结果提示 :癫痫发作急性期 ,延髓内脏带内星形胶质细胞可能参与了此病理过程 ,对机体应激反应 ,心血管调节、内环境稳定具有一定意义
Using the method of immunocytochemistry combined with animal behavioral observation, the model of auditory convulsion-susceptible rats was used to study the intima-astrocyte-astrocytic specificity in medulla oblongata from 30 min to 3 d after the ignition of epilepsy Changes in distribution of marker glial fibrillary acidic protein. The results showed that the number of small astrocytes began to increase 1 h after the epilepticus was ignited, especially in the nucleus tractus solitarius and the soft membrane. After 6 h, all the glial fibrillary acidic protein positive cells in the medullary visceral zone increased, Dorsomedial zone and ventral lateral zone were relatively dense with relatively few bands in the middle zone. After 1 day, the number of hypertrophic astrocytes began to increase; after 3d, the enlarged and deformed hypertrophic cells appeared. The results suggest that astrocytes in medulla oblongata may be involved in this pathological process during the acute phase of seizures and have some significance to stress response, cardiovascular regulation and internal environment stability