对15例房间隔缺损,19例室间隔缺损儿童进行了血浆心钠素(ANP),心脏指数(CI)和钠排泄分数(FENa％)相关性的研究。结果表明:34例先天性心脏病患儿血浆ANP水平明显高于正常对照组(217.23+83.04 VS 17.51±6.55)P<0.01。CI则明显低于正常对照组(3.32±0.35 VS 4.06±0.33)P<0.05。FENa％与正常对照组比较无明显差别(0.37±0.06 VS 0.38±0.07)P>0.05;34例患儿血浆ANP水平与CI呈负相关(r=-0.75,P<0.05)。提示:房室间隔缺损患儿血浆ANP水平可用来估价该类患儿的心功能。本组患儿血浆ANP水平升高同时FENa％正常,这一现象可能与机体ANP受体的再调节有关。 Atrial natriuretic peptide (ANP), cardiac index (CI) and sodium excretion fraction (FENa%) were studied in 15 children with atrial septal defect and 19 with ventricular septal defect. The results showed that the plasma levels of ANP in 34 children with congenital heart disease were significantly higher than those in the normal control group (217.23 + 83.04 VS 17.51 ​​± 6.55) P <0.01. CI was significantly lower than the normal control group (3.32 ± 0.35 VS 4.06 ± 0.33) P <0.05. There was no significant difference between FENa% and normal control group (0.37 ± 0.06 vs. 0.38 ± 0.07, P> 0.05). The plasma ANP level in 34 children was negatively correlated with CI (r = -0.75, P <0.05). Tip: children with atrioventricular septal plasma ANP levels can be used to assess the type of heart function in children. This group of children with elevated plasma ANP levels at the same time FENa% of normal, this phenomenon may be related to the body ANP receptor regulation.