新近的研究表明，细胞因子等多因素参与了多发性骨髓瘤（ＭＭ）的体液免疫抑制机制。本文着重介绍了Ｍ－蛋白分子、ＣＤ细胞、单核－巨噬细胞以及ＩＬ－６、ＩＬ－４异常与ＭＭ多克隆免疫球蛋白合成受抑之间关系的研究进展。文中涉及的急性期相蛋白（Ｃ－反应蛋白等）升高在ＭＭ的体液免疫抑制发生中的作用，可能对研究应激性疾病伴发体液免疫抑制的机理有所启发。 Recent studies have shown that cytokines and other factors are involved in the humoral immune suppression mechanism of multiple myeloma (MM). This article focuses on the research progress of the relationship between the abnormality of M-protein molecules, CD cells, monocytes-macrophages and IL-6, IL-4 and the inhibition of MM polyclonal immunoglobulin synthesis. The role of the acute phase protein (C-reactive protein, etc.) in the literature in the development of humoral immunosuppression in MM may be instructive for studying the mechanism of humoral immunosuppression associated with stress disease.