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β-羧乙基锗倍半氧化物(Ge-132)的无毒广谱抗癌作用以及潜在的治疗艾滋病的功能~[1～3]促进了Ge-132及其衍生物合成及生物活性研究~[4～6],而对锗原子直接与苯环及其衍生物连接的有机锗倍半氧化物的研究则相对较少.我们曾报道了~[7]p-(二甲氨基)苯基锗倍半氧化物的合成、结构及对癌细胞的作用,p-(二乙氨基)苯基锗倍半氧化物的研究尚未见报道.本文采用改进的方法合成了p-(二乙氨基)苯基锗倍半氧化物(Ge-164).通过元素分析、IP、XPS和TG-DTA确定了组成和结构,观察了它对体外培养人乳腺癌细胞有丝分裂的影响.
The non-toxic broad-spectrum anticancer effect of β-carboxyethylgermanium sesquioxide (Ge-132) and its potential for treatment of AIDS ~ 1 ~ 3 promoted the synthesis and bioactivity of Ge-132 and its derivatives However, relatively few studies on germanium sesquioxide bonded to germanium atoms directly to the benzene ring and its derivatives have been reported [4-6]. We have reported ~ [7] p- (dimethylamino) benzene The synthesis, structure and action of germanium sesquioxide on p-diethylamino phenyl germanium sesquioxide have not been reported in this paper.In this paper, p- (diethylamino ) Phenyl germanium sesquioxide (Ge-164). The composition and structure were determined by elemental analysis, IP, XPS and TG-DTA, and its effect on mitosis of human breast cancer cells in vitro was observed.