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酶测定用于癌症患者的辅助诊断时,要求能确定癌变或受累器官,指出病变程度,并供临床判定病变的进展或缓解。历来血清酶测定用于以上目的。近年来,为获得更特异的诊断方法,已试图测定组织、体液和体腔冲洗液的酶活性。本文讨论器官特异性酶、同功酶、组织与体液的酶测定、以及与其它生化或免疫化学测定相配合等在癌症患者的诊断与治疗中的作用。淀粉酶与脂酶综合许多研究表明,8～40%胰腺癌患者血清淀粉酶升高,检出率不高显然是
When enzyme assays are used to assist in the diagnosis of cancer patients, they must be able to identify cancerous or affected organs, indicate the extent of the lesions, and provide clinical judgment of the progression or remission of lesions. Serum enzyme assays have been used for these purposes. In recent years, in order to obtain more specific diagnostic methods, attempts have been made to determine the enzymatic activity of tissue, body fluids, and body cavity irrigation fluids. This article discusses the role of organ-specific enzymes, isoenzymes, tissue and body fluid enzymatic assays, and their combination with other biochemical or immunochemical assays in the diagnosis and treatment of cancer patients. Synthesis of Amylase and Lipase Many studies have shown that 8 to 40% of pancreatic cancer patients have elevated serum amylase and the detection rate is not high.