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为预防硬变肝叶切除所并发的内毒素血症,作者在肝切除前后投予OK-432,激活网状内皮系统,探讨对术后内毒素血症的影响。对象与方法:均为肝硬变合并肝细胞癌患者。OK-432投予组5例,非OK-432投予组7例。非硬变肝切除12例为对照组。在肝叶切除术前及术后1、3、7、14日取末梢静脉抗凝血,用合成基质法对内毒素定量。为激活网状内皮系统的机能,自肝切除2周前开始,隔日皮内注射OK-432,剂量分别为1、2、3、5、5、5KE。术后第5日起,每次注射5KE,每周2次。结果:肝叶切除前血中的内毒素,在非OK-432投予组为6.6±1.0pg/ml,与对照组2.6±0.5pg/ml 比较,显著增高。肝叶切除后非OK-432投予组血中内
In order to prevent endotoxemia complicated by hard hepatic lobectomy, the authors administered OK-432 before and after hepatectomy to activate the reticuloendothelial system to investigate the effect of postoperative endotoxemia. Subjects and methods: Patients with cirrhosis and hepatocellular carcinoma. There were 5 patients in the OK-432 group and 7 in the non-OK-432 group. Non-hardened hepatectomy in 12 patients was a control group. Peripheral vein anticoagulation was performed before hepatectomy and at 1, 3, 7 and 14 days after surgery. Endotoxin was quantified using a synthetic matrix method. In order to activate the function of the reticuloendothelial system, two weeks before the liver resection, OK-432 was injected intradermally every other day. The doses were 1, 2, 3, 5, 5, and 5 KE. From the 5th day after the operation, each injection of 5KE was performed twice a week. Results: The endotoxin in blood before hepatectomy was 6.6±1.0 pg/ml in non-Ok-432 administration group, and significantly higher than that in control group 2.6±0.5 pg/ml. Non-OK-432 administration in the blood after hepatectomy