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用改良K—H液灌流的大鼠离体工作心脏能在90min内保持稳定,120min时心肌收缩力和心输出量明显下降。结扎冠状动脉后心脏做功能力迅速下降,肌酸磷酸激酶释放量明显增加。结扎冠状动脉30min再灌流15min时心脏功能无明显恢复,而肌酸磷酸激酶释放量则进一步增加。1.4×10~(-4)M葛根素对正常大鼠离休工作心脏无明显抑制作用,能增加其冠脉流量。1.4×10(-4)M葛根素和10~(-5)M普萘洛尔均能明显降低冠脉结扎与再灌流时心肌肌酸磷酸激酶释放量,促进再灌流时心脏功能恢复,这是药物对心脏的直接保护作用。
The isolated rat working heart perfused with the modified K-H fluid remained stable within 90 min, and myocardial contractility and cardiac output decreased significantly at 120 min. After ligation of the coronary arteries, the heart’s ability to make a rapid decline, creatine phosphokinase release significantly increased. After coronary artery occlusion for 30 min and perfusion for 15 min, no significant recovery of cardiac function was observed, while the release of creatine phosphokinase was further increased. 1.4×10~(-4)M puerarin has no obvious inhibitory effect on the retired working heart of normal rats, and can increase the coronary flow. 1.4×10(-4)M puerarin and 10~(-5)M propranolol can significantly reduce myocardial creatine kinase release during coronary artery ligation and reperfusion, and promote cardiac function recovery during reperfusion. It is a direct protective effect of drugs on the heart.