论文部分内容阅读
生长因子的自分泌概念,是在研究分子和细胞基础的恶性转化中提出的统一题目。最近发现,癌基因能提供癌细胞生长因子自主性,从而导致过去独立的两个研究领域——癌基因和多肽生长因子——的统一。多年来,人们早就认识到恶性细胞具有相对的自主性。这就是,恶性细胞维持最佳生长和增殖所需要的外源性生长因子,比他们的正常对应细胞要少。为了解释这一现象,有人设想:细胞产生内源性多肽生长因子,这些因子作用于原来细胞的功能性外部受体,引起该细胞肽的表型表达,从而发生恶变。这一过程叫做自分泌。
The concept of autocrine of growth factors is a unified topic proposed in the study of the malignant transformation of molecular and cellular basis. It has recently been discovered that oncogenes can provide the autonomy of cancer cell growth factors, leading to the unification of two independent research areas in the past - oncogenes and polypeptide growth factors. Over the years, people have long recognized that malignant cells have relative autonomy. That is, the exogenous growth factors required for malignant cells to maintain optimal growth and proliferation are less than their normal counterparts. To explain this phenomenon, it was hypothesized that cells produce endogenous polypeptide growth factors that act on the functional external receptors of the original cell, causing the phenotypic expression of that cellular peptide and thereby causing malignant transformation. This process is called autocrine.