论文部分内容阅读
用正交试验设计筛选出氯化钾缓释包衣微丸的处方和工艺参数。释放度研究结果表明：以丸芯２为包衣底物，以ＥＣ＋阻滞剂为包衣材料，在３５℃的进气温度和８ｍｌ／ｍｉｎ的输液速度的条件下进行沸腾包衣，可以制得持续释药１２ｈ，在０～１０ｈ内近似零级释药的氯化钾缓释包衣微丸。
Orthogonal design was used to screen out the prescriptions and process parameters of potassium chloride sustained-release coated pellets. The results of the study of release showed that the ebullition coating was carried out using the pellet core 2 as the coating substrate and the EC + retarder as the coating material under the conditions of an inlet air temperature of 35 ° C and an infusion rate of 8 ml / min, Sustained release of 12h, within 0 ~ 10h similar to the release of potassium release-controlled release coated pellets.