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目的观察评价替吉奥联合三维适形放射治疗中晚期食管癌的近期疗效和毒性反应。方法选择本科2009年1-10月收治的56例不能或不愿手术的食管癌患者,分为替吉奥化疗增敏联合三维适形放疗组(实验组)和单一放疗组(对照组),每组28例。实验组于放疗同时口服替吉奥胶囊。对照组单一放疗。两组均采用三维适形放疗技术,每周5次,每次2.0Gy。实验组放疗总剂量为60～66Gy,在放疗第l天开始口服替吉奥胶囊60mg2次/d,14d为1个疗程,休息1周后继续口服第2个疗程;对照组放疗总剂量为60～66Gy。结果实验组和对照组放疗结束时获完全缓解分别为64.29%(18/28)和35.71%(10/28),有效率89.29%(25/28)和67.86%(19/28),两组相比均有统计学差异(P<0.05)。毒副作用主要为放射性食管炎、放射性气管炎、骨髓抑制、胃肠道反应等。结论替吉奥联合三维适形放射治疗食管癌提高了近期疗效。实验组毒副作用的发生率高于对照组,但均可以耐受。
Objective To observe and evaluate the short-term curative effect and toxic reaction of tegaserod combined with three-dimensional conformal radiotherapy for advanced esophageal cancer. Methods Fifty-six patients with esophageal cancer who could not or did not want surgery from January to October in 2009 were enrolled in this study. They were divided into three groups: experimental group and sensitized radiotherapy group (control group) 28 cases in each group. The experimental group was treated with radiotherapy for the same time. Control group single radiotherapy. Two groups were using three-dimensional conformal radiotherapy technology, 5 times a week, each 2.0Gy. In the experimental group, the total dose of radiotherapy was 60 ~ 66Gy. On the first day of radiotherapy, TEGO capsules were given 60mg twice a day for 14 days for one course of treatment. After one week of rest, the second course of oral treatment was continued. In the control group, the total dose of radiotherapy was 60 ~ 66Gy. Results The complete remission was 64.29% (18/28) and 35.71% (10/28) in the experimental group and the control group, the effective rates were 89.29% (25/28) and 67.86% (19/28), respectively. The two groups Compared with the statistical difference (P <0.05). The main side effects of radiation esophagitis, radiation bronchitis, bone marrow suppression, gastrointestinal reactions. Conclusion TGA combined with three-dimensional conformal radiotherapy for esophageal cancer has improved the short-term curative effect. The incidence of toxic side effects in experimental group than in the control group, but can be tolerated.