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目的了解本院不良反应发生的特点及引发药物不良反应(ADR)的相关因素,提高临床合理用药的水平。方法选取我院2013年上报的ADR报告286例。通过登陆药品不良反应监测系统导出报告生成Excel表,分别对ADR报告按年龄、性别、药品种类、给药途径及临床表现等方面进行统计分析。结果 ADR报告中67.1%是由医护人员报告的;63.3%的不良反应是由抗感染药物引起的;84.6%的不良反应是通过静脉滴注给药引起的;ADR涉及的系统器官以皮肤及其附件最多,其次是消化系统。结论不良反应的发生和很多因素有关:患者年龄、给药途径、药品种类等,必须加强药品规范使用的管理和完善药品不良反应报告制度。
Objective To understand the characteristics of adverse reactions in our hospital and the related factors that lead to adverse drug reaction (ADR), and to improve the level of clinical rational use of drugs. Methods 286 cases of ADR reported in our hospital in 2013 were selected. The report was generated by logging on the Adverse Drug Reaction Monitoring System and the Excel report was generated. The ADR reports were analyzed statistically by age, sex, drug type, route of administration and clinical manifestation. RESULTS: 67.1% of ADR cases were reported by medical staff; 63.3% of the adverse reactions were caused by anti-infective drugs; 84.6% of adverse reactions were caused by intravenous drip; Attachment up, followed by the digestive system. Conclusions The occurrence of adverse reactions is related to many factors, such as the age of patients, the route of administration and the types of medicines. The management of the standardized use of medicines and the reporting system of adverse drug reactions must be improved.