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食管癌是我国常见的恶性肿瘤,其早期诊断和监测复发与转移,对提高食管癌5年生存率尤为重要。循环肿瘤细胞(CTCs)是自发或因诊疗操作由实体瘤或转移灶释放进入外周血循环的一类肿瘤细胞。目前富集CTCs应用最广泛的方法是免疫磁珠富集技术,再通过形态学方法或分子检测法对其进行检测。目前尚无CTCs标准化的检测方案。将CTCs检测与TNM分期结合,在治疗前后动态检测CTCs水平,可反映治疗效果和预后,对临床医师评估治疗手段疗效及更改治疗方案提供重要依据。
Esophageal cancer is a common malignant tumor in our country. Its early diagnosis and monitoring of recurrence and metastasis are particularly important to improve 5-year survival rate of esophageal cancer. Circulating tumor cells (CTCs) are a group of tumor cells that are released into the peripheral bloodstream from solid tumors or metastases either spontaneously or during diagnostic procedures. At present, the most widely used method for enriching CTCs is immunomagnetic bead enrichment technology, which is then tested by morphological methods or molecular detection methods. There are currently no CTCs standardized test programs. CTCs combined with TNM staging, dynamic detection of CTCs levels before and after treatment can reflect the therapeutic effect and prognosis, and provide an important basis for clinicians to evaluate the curative effect of treatment and change treatment.