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以双同位素标记试餐SPECT技术检测17例活动性十二指肠溃疡(DU)患者和17例健康志愿者的胃排空功能,并以放免法测定其空腹和餐后胃泌素(GAS)和胃动素(MOT)水平。结果显示:58.8%患者固体食物的延迟相消失,起始排空较快,继后的排空变缓,液体和固体半排空均延迟,而食物胃内分布与对照组无异。DU患者GAS并无过度释放,而空腹及餐后MOT水平均高于对照组,但这与胃排空参数无显著相关性。这些结果提示活动性DU患者以食物胃排空延迟为主,MOT水平的改变可能是胃排空延迟反馈调节的结果,但胃排空延迟并未导致GAS过度释放。
The gastric emptying function in 17 patients with active duodenal ulcer (DU) and 17 healthy volunteers was detected by double isotope labeled test SPECT technique and the fasting and postprandial gastrin (GAS) And motilin (MOT) levels. The results showed that 58.8% of the patients had delayed disappearance of solid food, rapid initial emptying, subsequent emptying slowed down, liquid and solid half-emptying delayed, but the food distribution in the stomach was similar to the control group. There was no over-release of GAS in DU patients, while fasting and post-prandial MOT levels were higher than those in the control group, but there was no significant correlation with gastric emptying parameters. These results suggest that active DU patients with delayed gastric emptying of food-based, MOT level changes may be the result of delayed gastric emptying regulation, but delayed gastric emptying did not lead to excessive release of GAS.