长期应用抗癫疒间 药物 (AEDS)对儿童生长发育会造成一定的影响。AEDS 主要对儿童骨代谢、甲状腺功能、体重等产生影响。长期应用AEDS 可能会引起不同程度的骨代谢改变 ,主要是骨密度下降、骨生化指标异常 (骨形成减少或骨吸收增加 )。另外 ,长期应用AEDS 可造成甲状腺激素水平下降 ,引起亚临床型甲状腺功能减退。体重增加或减少也影响着儿童生长发育 ,但影响过程较为缓慢 ,临床表现轻重不一 ,往往被忽视。因此定期监测癫疒间 患儿的生长发育对提高其生活质量意义重大。 Long-term use of anti-epileptic drugs (AEDS) on children’s growth and development will have a certain impact. AEDS mainly affects children’s bone metabolism, thyroid function and body weight. Long-term use of AEDS may cause varying degrees of bone metabolism, mainly bone mineral density decline, bone biochemical abnormalities (reduced bone formation or increased bone resorption). In addition, long-term use of AEDS can cause thyroid hormone levels decreased, causing subclinical hypothyroidism. Weight gain or loss also affects children’s growth and development, but the impact of the process is more slow, clinical manifestations vary, often overlooked. Therefore, regular monitoring of children with epilepsy growth and development to improve their quality of life is of great significance.