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目的探讨同种输血和自体输血对肺鳞癌患者围术期肿瘤坏死因子 α(TNF α)和白细胞介素 10(IL 10 )的影响和相互关系。方法2 0 0 1年 1月至 2 0 0 3年 1月对 31例肺鳞癌患者行肺癌根治术 ,将其分为两组 ,同种输血组 (A组 ) 17例 ,自体输血组 14例 (B组 )。测定两组围术期血清中TNF α和IL 10的浓度。结果A组输血后d1与输血前相比血清中TNF α、IL 10浓度增高 ,以IL 10变化尤为明显 ,输血后d5TNF α降低并接近输血前的水平 ,明显低于B组 ,IL 10仍明显高于输血前的水平。B组中不同时间IL 10无显著变化 ,TNF α于d5明显高于输血前。结论肺鳞癌患者围术期同种输血后血清中TNF α降低与IL 10升高有关 ,IL 10升高可能是同种输血后免疫抑制的重要原因。自体输血可减轻或去除这一作用
Objective To investigate the effects of transfusions and autologous blood transfusion on tumor necrosis factor α (TNF α) and interleukin 10 (IL 10) in patients with squamous cell carcinoma of the lung. Method 2001 January January to January 2003 31 cases of lung squamous cell carcinoma patients underwent lung cancer radical surgery, divided into two groups, the same blood transfusion group (A group) in 17 cases, autologous blood transfusion Group of 14 patients (group B). The concentrations of TNFα and IL-10 in the perioperative serum of the two groups were measured. Results dAfter transfusion blood group d1 compared with before transfusion serum TNFα, IL 10 concentrations increased to IL 10 changes especially after transfusion d5TNF α decreased and close to the level before transfusion, was significantly lower than the B group, IL 10 Still significantly higher than the level before transfusion. In group B, there was no significant change in IL 10 at different times, and TNF α at d 5 was significantly higher than before transfusion. Conclusions 降 The decrease of TNFα in serum after perioperative blood transfusion in patients with squamous cell carcinoma of lung is related to the increase of IL-10, and the increase of IL-10 may be the important reason of immunosuppression after allo-transfusion. Autologous blood transfusion can reduce or eliminate this effect