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目的:探讨运用白细胞粘附分子LFA-1单抗和血管内皮细胞粘附分子ICAM-1单抗防治烧伤休克、改善微循环的作用机理.方法:复制大鼠烧伤休克模型,用红细胞跟踪相关仪和电视测微仪测量微静脉血液流速、口径、流量;镜下观察细静脉白细胞粘附数,并记录动物存活时间。结果:单抗能减缓烧伤休克大鼠平均动脉压和微静脉血流速度的下降趋势,显著降低微静脉的白细胞附壁粘着数,明显延长动物的存活时间,两种单抗同时使用的效果更好.结论:运用粘附蛋白单抗能阻断白细胞与内皮细胞的粘附,减少白细胞嵌塞微静脉,达到改善烧伤休克微循环和保护组织细胞的作用.
OBJECTIVE: To explore the mechanism of using microcosmic anti-burn shock and improving the microcirculation by using leucocyte adhesion molecule LFA-1 monoclonal antibody and vascular endothelial cell adhesion molecule ICAM-1 monoclonal antibody. Methods: The rat burn shock model was duplicated. The venous blood flow rate, caliber and flow rate were measured by erythrocyte tracking correlation meter and TV micrometer. The number of leukocyte adhesion was observed microscopically and the survival time was recorded. Results: Monoclonal antibody can slow the decline of average arterial pressure and venous flow velocity in burn shock rats, significantly reduce the number of leucocytes in the venules and significantly prolong the survival time of the animals, and the effect of the two mAbs simultaneously is more it is good. Conclusion: The adhesion protein monoclonal antibody can block the adhesion of leukocytes and endothelial cells, reduce the leucocyte implanted venules, and improve the microcirculation in burn shock and protect the tissue cells.