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目的通过安氏Ⅱ2类错家庭聚集性分析研究以及安氏Ⅱ2类错遗传度估算,探讨遗传因素在安氏Ⅱ2类错致病机制中的地位。方法采用遗传流行病学病例对照的方法,对126例安氏Ⅱ2类错先证家系及150例对照家系进行对照研究,比较一级亲属患病率。结果先证组一级亲属总的患病率为25.37%,明显高于对照组一级亲属总患病率(6.60%),患病病例分布的理论频数与实际频数比较差异有统计学意义(P<0.05),一级亲属遗传度估算值为92.26%。结论安氏Ⅱ2类错的发生具有家庭聚集性,遗传因素在该病致病机制中占有重要地位。
Objective To investigate the status of genetic factors in the pathogenesis of class Ⅱ division Ⅱ malocclusion by analyzing the family aggregation of class Ⅱ division Ⅱ malocclusion and the degree of genetic classification of class Ⅱ division Ⅱ malocclusions. Methods A case-control study was conducted in 126 cases of Class Ⅱclass malocclusion Ⅱ and 150 control pedigrees. The prevalence of first-degree relatives was compared. Results The overall prevalence of first-degree relatives in the first syndrome group was 25.37%, which was significantly higher than that of the first-degree relatives in the control group (6.60%). The difference between the theoretical frequency and the actual frequency of the diseased cases was statistically significant P <0.05). The first-degree relatives’ heritability was 92.26%. Conclusion The occurrence of Class Ⅱ 2 malocclusion has familial aggregation, and genetic factors play an important role in the pathogenesis of this disease.