血清γ-谷氨酰转移酶(GT.EC2.3.2.2)的测定常用作肝病的一种标志。比酶来源于肝胆管膜,并以不同的形式存在于血清中;大部份是与循环脂蛋白,特别是高密度脂蛋白(HDL)结合,但亦能与较大的低密度脂蛋白结合。此外较小的亲水型也有存在。在无黄疸病中是以HDL-GT 复合物为主,而胆汁郁积时,较大的分子型升高;然而,较小型的则能通过蛋白酶由肝膜结合状态释放,但在各种肝病中很少超 Serum γ-glutamyl transferase (GT.EC2.3.2.2) is often used as a marker of liver disease. The enzyme is derived from the hepatobiliary membrane and exists in different forms in the serum; most of it binds to circulating lipoproteins, especially high density lipoprotein (HDL), but also to larger low density lipoproteins . In addition, smaller hydrophilic type also exists. In the absence of jaundice, HDL-GT complexes are predominant, whereas larger cholestasis increases the molecular size; however, the smaller ones are released by proteases from the hepatic membrane but in a variety of liver diseases Very little super