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目的探讨原发性前列腺移行细胞癌的诊断与治疗方法。方法回顾性分析5例原发性前列腺移行细胞癌的临床资料。结果行TURP+放疗的患者术后12个月死亡。行膀胱造瘘术的患者及合并腺癌行TURP+双侧睾丸切除加内分泌治疗的患者分别于术后8个月、15个月死亡。1例行前列腺癌根治术者至今存活已30月,另1例行TURP+吡柔比星经尿道膀胱灌注化疗存活至今17月。结论本病早期诊断困难,确诊有赖于经直肠B超引导下前列腺穿刺活检或通过术后标本的病理检查,早期行前列腺癌根治术是较为有效的治疗方法,本病预后欠佳。
Objective To investigate the diagnosis and treatment of primary prostate transitional cell carcinoma. Methods The clinical data of 5 cases of primary prostate transitional cell carcinoma were retrospectively analyzed. Results TURP + radiotherapy patients died after 12 months. Patients undergoing cystostomy and patients with adenocarcinoma who underwent TURP + bilateral orchiectomy and endocrine therapy died at 8 and 15 months postoperatively. A routine radical prostatectomy patients have survived to 30 months, the other a TURP + pirarubicin transurethral bladder infusion chemotherapy survived so far in 17 months. Conclusion The early diagnosis of this disease is difficult. Diagnosis depends on transrectal B-guided prostate biopsy or postoperative pathological examination. Early radical prostatectomy is a more effective treatment. The prognosis of this disease is not good.