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原发性膀胱鳞癌较少见,约占所有膀胱癌的3～11.7%,5年生存率1.9～48%。流式细胞仪检测肿瘤细胞核 DNA 含量,常用于预测各种肿瘤恶性程度。1983年 Hedley 等在石腊包埋的病理标本中提取细胞核,应用流式细胞仪测定核 DNA 含量。本文作者按 Hedley 等介绍的这一新方法研究原发性膀胱癌,以了解肿瘤细胞核 DNA 倍体类型与肿瘤复发及患者生存之间的相关性。
Primary squamous cell carcinoma of the bladder is rare, accounting for approximately 3 to 11.7% of all bladder cancers, with a 5-year survival rate of 1.9 to 48%. Flow cytometry is used to detect the nuclear DNA content of tumor cells and is often used to predict the degree of malignancy of various tumors. In 1983, Hedley et al. extracted nuclei from paraffin-embedded pathological specimens and measured the nuclear DNA content using flow cytometry. The authors studied primary bladder cancer according to the new method described by Hedley et al. to understand the relationship between tumor cell nuclear DNA type and tumor recurrence and patient survival.