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菌斑细菌是牙周炎发生的始动因子。研究表明,除控制菌斑外,还可以通过调节宿主反应辅助治疗牙周炎。在宿主反应过程中,组织破坏性酶如MMPs、弹性蛋白酶等,炎症介质和细胞因子如PGE_2、IL-1、TNFα等起着非常重要的作用,介导了牙周组织的破坏。四环素类药物、NSAID、IL-1Ra、sIL-1R、抗TNFα单克隆抗体和sTNFR等可以选择性地阻断这些活性物质对牙周组织的破坏,起到良好的辅助治疗作用。
Plaque bacteria is the initiating factor of periodontitis. Studies have shown that, in addition to controlling plaque, but also through the host response to adjuvant treatment of periodontitis. During the host reaction, tissue destructive enzymes such as MMPs, elastase, inflammatory mediators and cytokines such as PGE_2, IL-1, TNFα play a very important role, which mediates the destruction of periodontal tissue. Tetracyclines, NSAIDs, IL-1Ra, sIL-1R, anti-TNFα monoclonal antibodies and sTNFR can selectively block the destruction of periodontal tissues by these active substances and play a good adjuvant therapeutic effect.