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大肠腺瘤内异型增生灶和癌灶,不仅有粘液含量和性质改变,而且有杯状细胞形态异常和潘氏细胞化生。本文着重讨论球状细胞形态异常和潘氏细胞化生与异型增生及癌变的关系。材料和方法选择本科1964～1984年间有明确异型增生或早期癌变的大肠腺瘤85例(共91个)。将原蜡块分别作连续切片3张,染HE、AB(pH2.5)/PAS和HID(pH1.0)/AB(pH2.5)以观察杯状细胞形态、粘液含量及性质、潘氏细胞化生和刷状缘分化等形态特征。另选潴留性息肉,增生性息肉各25例,炎性息肉12例作同样染色。以比较腺瘤和非腺瘤性息肉各种病变发生率差异。
In colorectal adenomas, heterogeneous metaplastic lesions and cancer lesions not only have altered mucus content and properties, but also have goblet cell abnormalities and Paneth cell metaplasia. This article focuses on the relationship between spherical cell morphology abnormalities and Paneth cell metaplasia and dysplasia and canceration. Materials and Methods 85 cases (91 in total) of colorectal adenomas with definite dysplasia or early canceration between 1964 and 1984 were selected. The original paraffin blocks were serially sectioned 3 times and stained with HE, AB (pH 2.5)/PAS and HID (pH 1.0)/AB (pH 2.5) to observe goblet cell morphology, mucus content and properties, Pan’s The morphological characteristics of cell differentiation and brush border differentiation. Retention of polyps, 25 cases of hyperplastic polyps, 12 cases of inflammatory polyps were similarly stained. To compare the incidence of various lesions in adenomas and non-adenomatous polyps.