SARS-CoV-2 is the virus responsible for COVID-19 disease,and since its emergence it has spread globally with the number of total cases in the tens of millions.COVID-19 presents with varied clinical manifestations that range from asymptomatic disease to severe respira-tory disease(pneumonia)with multiple organ failure and death.Several risk fac-tors have been associated with severe COVID-19 disease such as age,gender,diabetes,cardiovascular disease,treat-ments,and comorbidities that affect the immune system(Harrison et al.,2020).As is often the case for pathogen infec-tions,the host immune system is a key player in virus clearance and resolution of disease.Nevertheless,a wealth of evi-dence has emerged to implicate the host's immune system in the outcome of disease severity.In this case,an imbal-ance between inflammation and protec-tion leads to the progression to more severe disease.