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目的：探讨帕罗西汀联用奥氮平治疗青少年强迫症的疗效和安全性。方法将40例青少年强迫症患者按随机数字表法分为两组，每组20例，均口服帕罗西汀治疗，观察组在此基础上联合奥氮平治疗，观察8周。治疗前后采用Yale‐Browm强迫量表评定强迫状况，汉密顿抑郁量表评定抑郁状况，副反应量表评定不良反应。结果治疗第4周末起两组Yale‐Browm强迫量表、汉密顿抑郁量表评分较治疗前显著下降（P＜0．01），但观察组在治疗第4周末各量表评分显著低于对照组（P＜0．05），治疗第8周末 Yale‐Browm 强迫量表评分仍显著低于对照组（P＜0．05）。观察组治疗4周末总有效率为90．0％、8周末为95．0％，对照组分别为60．0％、70．0％，观察组治疗4周、8周末总有效率显著高于对照组（P＜0．05）。观察组不良反应发生率为20．0％，对照组为40．0％，两组比较差异无显著性（ P＞0．05）。结论帕罗西汀联合奥氮平治疗青少年强迫症具有协同增效作用，起效快，疗效显著，安全性高。“,”Objective To explore the efficacy and safety of paroxetine combined with aripiprazole in the treatment of adolescent obsessive‐compulsive disorder (OCD ) . Methods Forty adolescents with OCD were randomly divided into two groups of 20 ones each ,both groups took orally paroxetine ,on this basis observation group was plus aripiprazole foe 8 weeks .Obsessive conditions were assessed with the Yale –Brown Obsessive Compulsive Scale (Y‐BOCS) before and after treatment ,depressive conditions with the Hamilton Depression Scale (HAMD) ,and adverse reactions with the Treatment Emergent Symptom Scale (TESS) .Results Since the end of the 4th week the Y‐BOCS and HAMD scores of both groups lowered more significantly compared with pretreatment (P<0 .01) ,those were significantly lower in observation than in control group at the end of the 4th week (P<0 .05) ,so was the Y‐BOCS score at the end of the 8th week (P<0 .05) .The total effective rates were respectively 85% at the end of the 4th week and 95 .0% the 8th in the observation and 60 .0% and 75 .0% in control group ,the former significantly higher that the lat‐ter (P0 .05) .Conclusion Paroxetine combined with aripi‐prazole in the treatment of adolescent OCD has a synergism ,takes effect more rapidly ,and has an evident effect and higher safety .