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目的通过分析重庆市妇幼保健院70例新生儿败血症的致病菌种类及致病菌药敏试验,明确该院新生儿败血症主要的致病菌及有效抗生素,为有效治疗新生儿败血症提供有力指导。方法回顾性分析重庆市妇幼保健院确诊为新生儿败血症患儿的血培养及体外致病菌药敏试验结果。结果金黄色葡萄球菌28株(40.0%),大肠埃希茵16株(22.9%),表皮葡萄球菌12株(17.1%),腐生葡萄球菌8株(11.4%),草绿色链球菌4株(5.8%),肠球菌2株(2.8%)。金黄色葡萄球菌对苯唑西林敏感(96.4%),大肠埃希菌对头孢噻肟敏感(87.5%),表皮葡萄球菌对环丙沙星敏感(75.0%),腐生葡萄球菌对万古霉素敏感(87.5%),草绿色链球菌对青霉素敏感(100.0%),肠球菌对多西环素敏感(100.0%)。结论葡萄球菌属是新生儿败血症的主要致病菌,尤其是金黄色葡萄球菌,但其对苯唑西林治疗较为敏感。大肠埃希菌也是导致新生儿败血症的主要致病菌,对头孢噻肟治疗敏感。
OBJECTIVE: To analyze the pathogenic bacteria of 70 neonates with sepsis and drug sensitivity test in 70 maternal and child health centers in Chongqing, to identify the main pathogenic bacteria and effective antibiotics in neonatal septicemia in this hospital and to provide effective guidance for the effective treatment of neonatal sepsis. . Methods Retrospective analysis of Chongqing Municipal Maternal and Child Health Hospital diagnosed as neonatal septicemia in blood culture and in vitro pathogenic bacteria susceptibility test results. Results Staphylococcus aureus 28 (40.0%), Escherichia coli 16 (22.9%), Staphylococcus epidermidis 12 (17.1%), Staphylococcus saprophytic 8 (11.4%), Streptococcus viridans 4 5.8%), Enterococcus 2 strains (2.8%). Staphylococcus aureus is sensitive to oxacillin (96.4%), Escherichia coli is sensitive to cefotaxime (87.5%), Staphylococcus epidermidis is sensitive to ciprofloxacin (75.0%), saprophytic staphylococcus is sensitive to vancomycin (87.5%), Streptococcus viridans were sensitive to penicillin (100.0%) and Enterococcus was sensitive to doxycycline (100.0%). Conclusion Staphylococcus is the major causative agent of neonatal sepsis, especially Staphylococcus aureus, but it is more susceptible to oxacillin treatment. Escherichia coli is also the leading cause of neonatal sepsis and is sensitive to cefotaxime treatment.